For instance, I have two XP ISO's (so ~600 MB each). Each defrag'd (verified with contig.exe -v -a), yet an attempted compare runs extremely slowly with the lots of "flutter" (*not the correct terminology) in the disk read/write heads as they jump back & forth.
In cases where this happens, I don't believe it is necessarily a function of the file sizes involved.
Oops. Quoting myself, but here I go again. Mixing up two different features. File Compare vs. Compare Directories (with Content selected).(& irrespective of 2.52's "Up to 7x faster Compare Directories (by content) command for files on the same disk").
(Later I'll try to try the Compare Directories command to see if it responds similarly.)